MyD88 deficient Hydra reveal an ancient function of TLR-signaling in sensing bacterial colonizers.
Franzenburg S, Fraune S, Künzel S, Baines JF, Domazet-Lošo T, Bosch TC. MyD88-deficient Hydra reveal an ancient function of TLR signaling in sensing bacterial colonizers. Proceedings of the National Academy of Sciences. 2012 Nov 20;109(47):19374-9. https://doi.org/10.1073/pnas.1213110109
Blood system formation in the urochordate Ciona intestinalis requires the variable receptor vCRL1.
Sommer F, Awazu S, Anton-Erxleben F, Jiang D, Klimovich AV, Klimovich BV, Samoi˘ lovich MP, Satou Y, Krüss M, Gelhaus C, Kürn U. Blood system formation in the urochordate Ciona intestinalis requires the variable receptor vCRL1. Molecular biology and evolution. 2012 Oct 1;29(10):3081-93. https://doi.org/10.1093/molbev/mss120
Where simplicity meets complexity: hydra, a model for host-microbe interactions.
Embryo protection in contemporary immunology: Why bacteria matter.
Fraune S, Augustin R, Bosch TC. Embryo protection in contemporary immunology: Why bacteria matter. Communicative & integrative biology. 2011 Jul 1;4(4):369-72. https://doi.org/10.4161/cib.15159
In an early branching metazoan, bacterial colonization of the embryo is controlled by maternal antimicrobial peptides
Fraune S, Augustin R, Anton-Erxleben F, Wittlieb J, Gelhaus C, Klimovich VB, Samoilovich MP, Bosch TC. In an early branching metazoan, bacterial colonization of the embryo is controlled by maternal antimicrobial peptides. Proceedings of the National Academy of Sciences. 2010 Oct 19;107(42):18067-72. https://doi.org/10.1073/pnas.1008573107
Why bacteria matter in animal development and evolution.
Fraune S, Bosch TC. Why bacteria matter in animal development and evolution. BioEssays. 2010 Jul;32(7):571-80. https://doi.org/10.1002/bies.200900192
The dynamic genome of Hydra.
Chapman JA, Kirkness EF, Simakov O, Hampson SE, Mitros T, Weinmaier T, Rattei T, Balasubramanian PG, Borman J, Busam D, Disbennett K…. Bosch TC, et al. The dynamic genome of Hydra. Nature. 2010 Mar 25;464(7288):592-6. https://doi.org/10.1038/nature08830
How Hydra senses and destroys microbes.
Augustin R, Fraune S, Bosch TC. How Hydra senses and destroys microbes. In Seminars in immunology 2010 Feb 1 (Vol. 22, No. 1, pp. 54-58). Academic Press. https://doi.org/10.1016/j.smim.2009.11.002
Disturbing epithelial homeostasis in the metazoan Hydra leads to drastic changes in associated microbiota.
Fraune S, Abe Y, Bosch TC. Disturbing epithelial homeostasis in the metazoan Hydra leads to drastic changes in associated microbiota. Environmental Microbiology. 2009 Sep;11(9):2361-9. https://doi.org/10.1111/j.1462-2920.2009.01963.x
More than just orphans: are taxonomically-restricted genes important in evolution?
Khalturin K, Hemmrich G, Fraune S, Augustin R, Bosch TC. More than just orphans: are taxonomically-restricted genes important in evolution?. Trends in Genetics. 2009 Sep 1;25(9):404-13. https://doi.org/10.1016/j.tig.2009.07.006
Uncovering the evolutionary history of innate immunity: the simple metazoan Hydra uses epithelial cells for host defence.
Bosch TC, Augustin R, Anton-Erxleben F, Fraune S, Hemmrich G, Zill H, Rosenstiel P, Jacobs G, Schreiber S, Leippe M, Stanisak M. Uncovering the evolutionary history of innate immunity: the simple metazoan Hydra uses epithelial cells for host defence. Developmental & Comparative Immunology. 2009 Apr 1;33(4):559-69. https://doi.org/10.1016/j.dci.2008.10.004
Plasticity of epithelial cell shape in response to upstream signals: a whole-organism study using transgenic Hydra.
Anton-Erxleben F, Thomas A, Wittlieb J, Fraune S, Bosch TC. Plasticity of epithelial cell shape in response to upstream signals: a whole-organism study using transgenic Hydra. Zoology. 2009 May 15;112(3):185-94. https://doi.org/10.1016/j.zool.2008.09.002