Prof.

Thomas Bosch

Vita

Academic Appointments

Since 2000
Professor (C4) and Director, Zoological Institute, Christian-Albrechts-University Kiel

2010 – 2013
Vice President of Christian-Albrechts-University Kiel

Since 2013
Head/Director of Interdisciplinary Research Center « Kiel Life Science » (KLS)

Since 2016
Head/ Spokesperson Collaborative Research Center (CRC / SFB 1182) “Origins and functions of metaorganisms”

1997 -1999
Professor (C3) „Spezielle Zoologie“ at the Friedrich-Schiller University Jena

1993 -1997
Junior Faculty (Oberassistent, Privatdozent C2), Zoological Institute, University of Munich


Education/Training

1976 – 1983
Study of Biology at University of Munich and University College Swansea, UK

1983 – 1986
Doctoral student, Zoological Institute, University of Munich

1986 – 1988
Post-Doc (Feodor Lynen fellow of Alexander-von-Humboldt Foundation) at the Developmental Biology Center, University of California, Irvine, USA

1988 – 1993
Research Assistant, Zoological Institute, University of Munich

1993
Habilitation in „Zoologie“, University of Munich


Major research interests

Evolutionary Developmental Biology; Zoology; Comparative genomics; host-microbiota interactions; the influence of bacteria on animal development; the evolution of animal-bacterial interactions


Personal

Birth Date: 3 September 1955. German Citizen


Current main grants and functions

Since 2013
Head/Speaker Interdisciplinary Research Center «Kiel Life Science» (KLS) at the University of Kiel

Since 2016
Spokesperson, DFG Collaborative Research Center (CRC/SFB 1182) „Origin and Function of Metaorganisms” 2016-2024: ca 22 million € to the consortium.

Since 2016
Fellow, Canadian Institute for Advanced Research (CIFAR), Human and the Microbiome Program

Since 2021
Principal Investigator, Collaborative Research Center CRC 1461 (SFB 1461) “Neurotronics: Bioinspired information processing” at the University of Kiel . Project A1 (626.900,00 €)

2022
Président de la Conferences Jacques Monod “Comparative Biology of Aging”. Roscoff November 2022

2023
Chair, Gordon Research Conference “Animal-Microbe symbioses”, June 2023 Italy


Fellowships, important rewards

1986
Feodor Lynen Fellowship (Alexander-von-Humboldt Foundation)

1998
Honorary Professorship St. Petersburg State University, Russia

2004
Doctor „honoris causa“ from St. Petersburg State University, Russia

2009
De Bary Lecture, University of Vienna

2010
Carl-Friedrich-von-Siemens Foundation Lecture, Munich

2014
Koshland Lecture Award, University of Chicago, USA

2016
Distinguished Lecturer, King Abdullah University Science Technology (KAUST), Saudi Arabia

Since 2016
Senior Fellow, Canadian Institute for Advanced Research (CIFAR)

2016
Peter Hemmerich Vorlesung, Universität Konstanz

2018
Fellow, Wissenschaftskolleg zu Berlin / Institute for Advanced Study in Berlin, Academic Year 2018/2019

2018
Kane Memorial Lecturer, University of Hawaii

2019
The Hilgendorf Lecture, Univ Tübingen

2020/2021
The René Touraine lecturer, Europ Soc Dermatol Research (ESDR), Sept 2020, Amsterdam

2022
Wissenschaftspreis der Deutschen Zoologischen Gesellschaft (DZG) – Karl-Ritter-von-Frisch-Medaille


Most significant contributions to science

My work helped to develop new paradigms across a range of evolutionary developmental biology topics. My work also discovered early emerging metazoans as holobionts/metaorganisms and helped to identify fundamental components and mechanisms through which an animal host regulates its microbiome.

I. Evolution of stem cells

As a junior scientist I discovered that ancestral metazoans have multipotent stem cells capable to differentiate into both somatic and germline lineages (Bosch & David 1986, Proc. Nat. Acad. Sci. USA. 83; Bosch TCG and CN David, 1987, Dev.Biol.121, 170 citations). My work also uncovered FoxO as one of evolutionary conserved genes controlling stem cell biology, stem cell aging and immunoaging (Boehm et al, 2012, Proc Natl Acad Sci USA, 109(48), 172 citations). More recently we discovered that tissue homeostasis in Hydra can be dysregulated by environmental factors leading to tumor formation (Domazet-Lošo et al, 2014, Nature Communications 5/1, 102 citations)

II. Method Development

Over the course of the years we developed a number of methods which represent a significant community resources and are widely used by dev biologists (Lohmann J, HP Schickle and TCG Bosch (1995) REN, a rapid, efficient and non-radioactive method for differential display and isolation of mRNA, BioTechniques 18 (146 citations).
I participated in an international project to sequence the Hydra magnipapillata genome. The research generated numerous publications, including a full-length article (and accompanying ‘News & Views’) in the pages of Nature (Chapman et al (2010) The dynamic genome of Hydra, Nature 464, 732 citations). With our homemade “Compagen” platform we developed a comparative genomics platform for early branching metazoan animals (G Hemmrich, TCG Bosch, Bioessays 30 (10), 1010-1018; 109 citations)
Most significantly, my lab developed a robust method to generate transgenic Hydra polyps (Lohmann J, I Endl & TCG Bosch (1999) Silencing of developmental genes in Hydra. Developmental Biology, 214: 211-214, 324 citations ; Wittlieb J, Khalturin K, Lohmann JU, Anton-Erxleben F and Bosch TCG (2006) Transgenic Hydra allow in vivo tracking of individual stem cells during morphogenesis. Proc. Natl. Acad. Sci. USA 103, 295 citations). Klimovich A, Wittlieb J, Bosch TCG (2019) Transgenesis in Hydra to characterize gene function and visualize cell behaviour. Nature Protocol

III. Ancestral Mechanisms mediating patterning formation

Throughout my career I have made substantial contributions to our understanding of the evolution of development (Weinziger, …, Bosch (1994): Ks1, an epithelial cell specific gene, responds to early signals of head formation in Hydra. Development 120; Endl I, J Lohmann and TCG Bosch (1999) Head specific gene expression in Hydra, PNAS 96, 1445-1450; Lohmann & Bosch (2000) The novel peptide HEADY specifies apical fate in a simple, radially symmetric metazoan. Genes and Development, 14 (21); Augustin, …, Bosch TCG (2006) Dickkopf related genes are components of the positional value gradient in Hydra. Dev. Biol. 296. Bosch: Why polyps regenerate and we don’t: Towards a cellular and molecular framework for Hydra regeneration, Dev Biol 303 (2) (217 citations). Mortzfeld , … Bosch (2019). Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways, Nature Comm.; López-Quintero, …, Bosch TCG (2019) Boundary maintenance in the ancestral metazoan Hydra depends on histone acetylation, Developmental Biology). Khalturin, …, Bosch: More than just orphans: are taxonomically-restricted genes important in evolution? Trends in Genetics 25 (9) (368 citations)

IV. Origin and function of symbiosis and host-microbiota interactions

My work helped to develop new concepts and paradigms in host-microbiome research across a range of topics (“Metaorganisms as the New Frontier”, Bosch & McFall-Ngai (2011) Zoology 114 (4), 303 citations). Fraune & Bosch (2007): Long-term maintenance of species-specific bacterial microbiota in the basal metazoan Hydra. PNAS 104 (32) (340 citations). Fraune & Bosch (2010) Why bacteria matter in animal development and evolution, Bioessays 32 (7) (277 citations), Bosch TCG (2013) Cnidarian-Microbe Interactions and the Origin of Innate Immunity in Metazoans. Ann Rev Microbiol Vol 67, 499-518, 138 citations ; McFall-Ngai et al 2013: Animals in a bacterial world, a new imperative for the life sciences. Proc Natl Acad Sci U S A. 2013;110(9), 1850 citations ; Gilbert SF, TCG Bosch, C Ledón-Rettig (2015) Eco-Evo-Devo: developmental symbiosis and developmental plasticity as evolutionary agents. Nature Reviews Genetics 16(10), 273 citations).

My current research specializes in beneficial relationships between animals and bacteria, including the establishment and maintenance of symbiosis, the evolution of these interactions, and how they affect the animal’s health. Specifically, we discovered that in Hydra there is a species specific microbiota which is an integral part of the innate immune system (Fraune S and Bosch TCG (2007) Long-term maintenance of species-specific bacterial microbiota in the basal metazoan Hydra. PNAS 104, 332 citations). Similar patterns have been observed in taxonomically diverse animal groups and this is now believed to be a universal principle of animal-microbe symbiosis (Bordenstein & Theis, 2015; McFall-Ngai et al., 2013; Zilber-Rosenberg & Rosenberg, 2008). My work has shown that the innate immune system and its antimicrobial peptides are used to shape the microbiome ( Fraune , … Bosch (2010) In an early branching metazoan, bacterial colonization of the embryo is controlled by maternal antimicrobial peptides, Proc. Natl. Acad. Sci. USA , 107, 134 citations; Distinct antimicrobial peptide expression determines host species-specific bacterial associations (S Franzenburg, J Walter, S Künzel, J Wang, JF Baines, TCG Bosch, … (2013) PNAS 110 (39), 249 citations). Bosch & Zasloff(2021) mBio; that communication between host and microbiota is done by conserved innate immune pathways (Franzenburg, …, Bosch (2012) MyD88 deficient Hydra reveal ancient function of TLR-signaling in sensing bacterial colonizers. PNAS 109 (47), 136 citations). Taubenheim J, Willoweit-Ohl D, Knop M, Franzenburg S, He J, Bosch TCG, Fraune S (2020) Bacteria- and temperature-regulated peptides modulate beta-catenin signalling in Hydra. Proc Natl Acad Sci USA); that ancient nervous systems interact with the local microbiota and that the microbiota affects the nervous system (Augustin , … Bosch (2017) A secreted antibacterial neuropeptide shapes the microbiome in Hydra: Nature Comm., 8(1):69; Klimovich … Bosch TCG (2020) Prototypical pacemaker neurons interact with the resident microbiota. Proc Natl Acad Sci US,; Murillo-Rincon … Bosch TCG (2017) Spontaneous body contractions are modulated by the microbiome of Hydra. Sci Rep. 7(1):15937); and that metabolic co-dependence drives the evolutionarily ancient Hydra-Chlorella symbiosis (Hamada … Bosch TCG (2018) Metabolic co-dependence. eLife 2018;7:e35122).

In the last decade I have built one of the strongest interdisciplinary host-microbiome programs in Germany (CRC1182) coordinating the research efforts of >20 scientists at 8 institutions. The project is supported by the German Science Foundation DFG and lead to high international visibility (Chair of Gordon Conference; CIFAR Fellow). I am now a recognized thought leader regarding the cornerstone role microbiota play in the life sciences.


Represantative publications

Google Scholar statistics: ~16921 citations (~8147 since 2018)
h-index=66, i10-index=156

Publications


Handbooks

Bosch TCG (Ed.) (2008) “Stem Cells: From Hydra to Man”.192 pages. Springer Netherlands (2008) ISBN-10: 1402082738;

Bosch TCG and D Miller (2016): The Holobiont Imperative: Perspectives from Early Emerging Animals. Springer New York,

Bosch TCG & M Hadfield (Eds.) (2020) Cellular Dialogues in the Holobiont. CRC Press, London, New York, ISBN 978-0-367-22881-1


Popular science writing

I am committed to the process of communicating science and research to non-specialist audiences.

Bosch TCG (2017) Der Mensch als Holobiont – Mikroben als Schlüssel zu einem neuen Verständnis von Leben und Gesundheit, paperback. Ludwig Verlag.

Bosch TCG (2022) Die Unentbehrlichen – Mikroben, des Körpers verborgene Helfer. Warum sind so viele Menschen krank? Antworten aus der Mikrobiomforschung. Springer Fachbuch. ISBN 978-3-662-65082-0

Publications

2023

Spontaneous body wall contractions stabilize the fluid microenvironment that shapes host-microbe associations.

Nawroth JC, Giez C, Klimovich A, Kanso E, Bosch TC. Spontaneous body wall contractions stabilize the fluid microenvironment that shapes host–microbe associations. Elife. 2023 Jul 3;12:e83637. https://doi.org/10.7554/eLife.83637

 

2022

Beyond Lynn Margulis’ green hydra.

Carrier, T & TCG Bosch (2022) Symbiosis: the other cells in development. Development 149(13):dev200797. doi: DOI: 10.1242/dev.200797

2022

Symbiotic Algae of Hydra viridissima Play a Key Role in Maintaining Homeostatic Bacterial Colonization.

Bathia J, Schröder K, Fraune S, Lachnit T, Rosenstiel P, Bosch TC. Symbiotic Algae of Hydra viridissima Play a Key Role in Maintaining Homeostatic Bacterial Colonization. Frontiers in microbiology. 2022 Jun 6;13:869666. https://doi.org/10.3389/fmicb.2022.869666

2022

Symbiont transmission in marine sponges: reproduction, development, and metamorphosis

Carrier TJ, Maldonado M, Schmittmann L, Pita L, Bosch TC, Hentschel U. Symbiont transmission in marine sponges: reproduction, development, and metamorphosis. BMC Biology. 2022 May 6;20(1):100. https://doi.org/10.1186/s12915-022-01291-6

2022

Wenn das Mikrobiom den Nerven trifft: Hydra hilft den Blick auf die Interaktion von Mikroben und Nervenzellen zu vertiefen

Bosch T, Giez C. Wenn das Mikrobiom den Nerven trifft: Hydra hilft den Blick auf die Interaktion von Mikroben und Nervenzellen zu vertiefen. Biologie in unserer Zeit. 2022 Sep 13;52(4):352-62. https://doi.org/10.11576/biuz-5866

2022

Hydra´s lasting partnership with microbes: key for escaping senescence?

He J, Bosch TC. Hydra’s Lasting Partnership with Microbes: The Key for Escaping Senescence?. Microorganisms. 2022 Apr 4;10(4):774. https://doi.org/10.3390/microorganisms10040774

 

2022

Hydra and the hair follicle – An unconventional comparative biology approach to exploring the human holobiont.

Lousada MB, Lachnit T, Edelkamp J, Paus R, Bosch TC. Hydra and the hair follicle–An unconventional comparative biology approach to exploring the human holobiont. BioEssays. 2022 May;44(5):2100233. https://doi.org/10.1002/bies.202100233

2022

The role of DNA methylation in genome defense in Cnidaria and other invertebrates

Ying H, Hayward DC, Klimovich A, Bosch TC, Baldassarre L, Neeman T, Forêt S, Huttley G, Reitzel AM, Fraune S, Ball EE. The role of DNA methylation in genome defense in Cnidaria and other invertebrates. Molecular Biology and Evolution. 2022 Feb 1;39(2):msac018. https://doi.org/10.1093/molbev/msac018

 

2021

Antimicrobial Peptides—or How Our Ancestors Learned to Control the Microbiome

Bosch TC, Zasloff M. Antimicrobial peptides—or how our ancestors learned to control the microbiome. MBio. 2021 Oct 26;12(5):10-128. https://doi.org/10.1128/mbio.01847-21

2021

Making the invisible visible: exploring host–microbiome interactions across different taxa using data-driven 3D visualization

Landis SH, Duscher T, Bosch TC. Making the invisible visible: exploring host–microbiome interactions across different taxa using data-driven 3D visualization. The Biochemist. 2021 Oct 1;43(5):40-5. https://doi.org/10.1042/bio_2021_164

2021

Taking a microscale look at symbiotic interactions—and why it matters

Bosch TC. Taking a microscale look at symbiotic interactions—and why it matters. Proceedings of the National Academy of Sciences. 2021 Aug 3;118(31):e2110874118. https://doi.org/10.1073/pnas.2110874118

2021

Neurons interact with the microbiome: an evolutionary-informed perspective

Giez C, Klimovich A, Bosch TC. Neurons interact with the microbiome: an evolutionary-informed perspective. Neuroforum. 2021 May 26;27(2):89-98. https://doi.org/10.1515/nf-2021-0003

2021

Animal development in the microbial world: Re-thinking the conceptual framework. 

Bosch TC, McFall-Ngai M. Animal development in the microbial world: Re-thinking the conceptual framework. In Current topics in developmental biology 2021 Jan 1 (Vol. 141, pp. 399-427). Academic Press. https://doi.org/10.1016/bs.ctdb.2020.11.007

2021

Animal development in the microbial world: The power of experimental model systems.

McFall-Ngai M, Bosch TC. Animal development in the microbial world: The power of experimental model systems. Current topics in developmental biology. 2021 Jan 1;141:371-97. https://doi.org/10.1016/bs.ctdb.2020.10.002

2021

The hygiene hypothesis, the COVID pandemic, and consequences for the humanmicrobiome

Finlay BB, Amato KR, Azad M, Blaser MJ, Bosch TC, Chu H, Dominguez-Bello MG, Ehrlich SD, Elinav E, Geva-Zatorsky N, Gros P. The hygiene hypothesis, the COVID pandemic, and consequences for the human microbiome. Proceedings of the National Academy of Sciences. 2021 Feb 9;118(6):e2010217118. https://doi.org/10.1073/pnas.2010217118

2020

Bacteria- and temperature-regulated peptides modulate beta-catenin signalling in Hydra

Taubenheim J, Willoweit-Ohl D, Knop M, Franzenburg S, He J, Bosch TC, Fraune S. Bacteria-and temperature-regulated peptides modulate β-catenin signaling in Hydra. Proceedings of the National Academy of Sciences. 2020 Sep 1;117(35):21459-68. https://doi.org/10.1073/pnas.2010945117

 

2020

Exploring the niche concept in a simple metaorganism

Deines P, Hammerschmidt K, Bosch TC. Exploring the niche concept in a simple metaorganism. Frontiers in microbiology. 2020 Aug 11;11:1942. https://doi.org/10.3389/fmicb.2020.01942

2020

Microbial species coexistence depends on the host environment

Deines P, Hammerschmidt K, Bosch TC. Microbial species coexistence depends on the host environment. MBio. 2020 Aug 25;11(4):10-128. https://doi.org/10.1128/mbio.00807-20

2020

Prototypical pacemaker neurons interact with the resident microbiota

Klimovich A, Giacomello S, Björklund Å, Faure L, Kaucka M, Giez C, Murillo-Rincon AP, Matt AS, Willoweit-Ohl D, Crupi G, de Anda J, Wong GCL, D’Amato M, Adameyko I, Bosch TCG. Prototypical pacemaker neurons interact with the resident microbiota. Proceedings of the National Academy of Sciences. 2020 Jul 28;117(30):17854-63. https://doi.org/10.1073/pnas.1920469117

2020

Dynamic interactions within the host-associated microbiota cause tumor formation in the basal metazoan Hydra.

Rathje K, Mortzfeld B, Hoeppner MP, Taubenheim J, Bosch TC, Klimovich A. Dynamic interactions within the host-associated microbiota cause tumor formation in the basal metazoan Hydra. PLoS Pathogens. 2020 Mar 19;16(3):e1008375. https://doi.org/10.1371/journal.ppat.1008375

 

2020

Are noncommunicable diseases communicable?

Finlay BB,  Blaser MJ, Bosch TCG, Dominguez-Bello MG, Elinav E, McFall-Ngai M, Melby MK, Muehlmann SR,  Sansonetti PJ (2020) Science. 367(6475): 250-251. doi: 10.1126/science.aaz3834 

2020

Bdellovibrio and like organisms are predictors of microbiome diversity across diverse host groups.

Johnke J, Fraune S, Bosch TC, Hentschel U, Schulenburg H. Bdellovibrio and like organisms are predictors of microbiome diversity in distinct host groups. Microbial ecology. 2020 Jan;79(1):252-7. https://doi.org/10.1007/s00248-019-01395-7

2019

Comparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms

Rausch P, Rühlemann M, Hermes BM, Doms S, Dagan T, Dierking K, Domin H, Fraune S, Von Frieling J, Hentschel U, Heinsen FA. et al. Comparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms. Microbiome. 2019 Dec;7(1):1-9. https://doi.org/10.1186/s40168-019-0743-1

2019

Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways

Mortzfeld BM, Taubenheim J, Klimovich AV, Fraune S, Rosenstiel P, Bosch TC. Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways. Nature Communications. 2019 Jul 22;10(1):3257. https://doi.org/10.1038/s41467-019-11136-6

2019

Neutrality in the metaorganism

Sieber M, Pita L, Weiland-Bräuer N, Dirksen P, Wang J, Mortzfeld B, Franzenburg S, Schmitz RA, Baines JF, Fraune S, Hentschel U. et al. Neutrality in the metaorganism. PLoS Biology. 2019 Jun 19;17(6):e3000298. https://doi.org/10.1371/journal.pbio.3000298

2019

Transgenesis in Hydra to characterize gene function and visualize cell behaviour.

Klimovich A, Wittlieb J, Bosch TC. Transgenesis in Hydra to characterize gene function and visualize cell behavior. Nature Protocols. 2019 Jul;14(7):2069-90. https://doi.org/10.1038/s41596-019-0173-3

2019

The microbiome mediates environmental effects on ageing

Finlay BB, Pettersson S, Melby MK, Bosch TC. The microbiome mediates environmental effects on aging. BioEssays. 2019 Oct;41(10):1800257. https://doi.org/10.1002/bies.201800257

2019

Evolutionary “experiments” in symbiosis: the study of model animals provides insights into the mechanisms underlying diversity of host-microbe interactions

Bosch TC, Guillemin K, McFall‐Ngai M. Evolutionary “experiments” in symbiosis: the study of model animals provides insights into the mechanisms underlying the diversity of host–microbe interactions. BioEssays. 2019 Oct;41(10):1800256. https://doi.org/10.1002/bies.201800256

2019

Exposure of the host-associated microbiome to nutrient-rich conditions may lead to dysbiosis and disease development – an evolutionary perspective.

Lachnit T, Bosch TC, Deines P. Exposure of the host-associated microbiome to nutrient-rich conditions may lead to dysbiosis and disease development—an evolutionary perspective. MBio. 2019 Jun 25;10(3):10-128. https://doi.org/10.1128/mbio.00355-19

2019

Resolving structure and function of metaorganisms through a holistic framework 2 combining reductionist and integrative approaches

Jaspers C, Fraune S, Arnold AE, Miller DJ, Bosch TC, Voolstra CR. Resolving structure and function of metaorganisms through a holistic framework combining reductionist and integrative approaches. Zoology. 2019 Apr 1;133:81-7. https://doi.org/10.1016/j.zool.2019.02.007

2018

Hydra as Model to Determine the Role of FOXO in Longevity

Bosch TC. Hydra as Model to Determine the Role of FOXO in Longevity. FOXO Transcription Factors: Methods and Protocols. 2019:231-8.

2018

Metabolic co-dependence drives the evolutionarily ancient Hydra-Chlorella symbiosis.

Hamada M, Schröder K, Bathia J, Kürn U, Fraune S, Khalturina M, Khalturin K, Shinzato C, Satoh N, Bosch TC. Metabolic co-dependence drives the evolutionarily ancient Hydra–Chlorella symbiosis. Elife. 2018 May 31;7:e35122. https://doi.org/10.7554/eLife.35122

2018

Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy

Von Frieling J, Fink C, Hamm J, Klischies K, Forster M, Bosch TC, Roeder T, Rosenstiel P, Sommer F. Grow with the challenge–microbial effects on epithelial proliferation, carcinogenesis, and cancer therapy. Frontiers in microbiology. 2018 Sep 20;9:2020. https://doi.org/10.3389/fmicb.2018.02020

2018

Non-senescent Hydra tolerates severe disturbances in the nuclear lamina.

Klimovich A, Rehm A, Wittlieb J, Herbst EM, Benavente R, Bosch TC. Non-senescent Hydra tolerates severe disturbances in the nuclear lamina. Aging (Albany NY). 2018 May;10(5):951. https://doi.org/10.18632/aging.101440

 

2018

Carrying capacity and colonization dynamics of Curvibacter in the Hydra host habitat

Wein T, Dagan T, Fraune S, Bosch TC, Reusch TB, Hülter NF. Carrying capacity and colonization dynamics of Curvibacter in the Hydra host habitat. Frontiers in microbiology. 2018 Mar 14;9:443. https://doi.org/10.3389/fmicb.2018.00443

2018

Stem cell transcription factor FoxO controls microbiome resilience in Hydra.

Mortzfeld BM, Taubenheim J, Fraune S, Klimovich AV, Bosch TC. Stem cell transcription factor FoxO controls microbiome resilience in Hydra. Frontiers in Microbiology. 2018 Apr 3;9:629. https://doi.org/10.3389/fmicb.2018.00629

2018

Metaorganisms in extreme environments: do microbes play a role in organismal adaptation?

Bang C, Dagan T, Deines P, Dubilier N, Duschl WJ, Fraune S, Hentschel U, Hirt H, Hülter N, Lachnit T, Picazo D, Pita L, Pogoreutz C, Rädecker N, Saad MM, Schmitz RA, Schulenburg H, Voolstra CR, Weiland-Bräuer N, Ziegler M, Bosch TCG. Metaorganisms in extreme environments: do microbes play a role in organismal adaptation?. Zoology. 2018 Apr 1;127:1-9. https://doi.org/10.1016/j.zool.2018.02.004

2018

How the microbiome challenges our concept of self.

Rees T, Bosch T, Douglas AE. How the microbiome challenges our concept of self. PLoS Biology. 2018 Feb 9;16(2):e2005358. https://doi.org/10.1371/journal.pbio.2005358

2017

Temperate phages as self-replicating weapons in bacterial competition.

Li XY, Lachnit T, Fraune S, Bosch TC, Traulsen A, Sieber M. Temperate phages as self-replicating weapons in bacterial competition. Journal of The Royal Society Interface. 2017 Dec 31;14(137):20170563. https://doi.org/10.1098/rsif.2017.0563

2017

Spontaneous body contractions are modulated by the microbiome of Hydra.

Murillo-Rincon AP, Klimovich A, Pemöller E, Taubenheim J, Mortzfeld B, Augustin R, Bosch TC. Spontaneous body contractions are modulated by the microbiome of Hydra. Scientific Reports. 2017 Nov 21;7(1):15937. https://doi.org/10.1038/s41598-017-16191-x

2017

A secreted antibacterial neuropeptide shapes the microbiome of Hydra.

Augustin R, Schröder K, Murillo Rincón AP, Fraune S, Anton-Erxleben F, Herbst EM, Wittlieb J, Schwentner M, Grötzinger J, Wassenaar TM, Bosch TC. A secreted antibacterial neuropeptide shapes the microbiome of Hydra. Nature Communications. 2017 Sep 26;8(1):698. https://doi.org/10.1038/s41467-017-00625-1

 

2016

The Origin of Mucosal Immunity: Lessons from the Holobiont Hydra.

Schröder K, Bosch TC. The origin of mucosal immunity: lessons from the holobiont Hydra. MBio. 2016 Dec 30;7(6):10-128. https://doi.org/10.1128/mbio.01184-16

2016

Transitioning from Microbiome Composition to Microbial Community Interactions: The Potential of the Metaorganism Hydra as an Experimental Model.

Deines P, Bosch TC. Transitioning from microbiome composition to microbial community interactions: the potential of the metaorganism Hydra as an experimental model. Frontiers in microbiology. 2016 Oct 13;7:1610. https://doi.org/10.3389/fmicb.2016.01610